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Lesson: Chapter 20 — Heredity

20.6. Genetic disorders 1 of 7

Sex-linked inheritance

The sex chromosomes carry ordinary genes as well as deciding sex. Because the X and the Y are not the same size, those genes do not behave the way genes on the autosomes do.

Sex-linked characteristics

Characteristics controlled by genes carried on the sex chromosomes are called sex-linked. In practice this nearly always means the X chromosome, because the much smaller Y carries very few genes.

One X against two

For a gene on the X chromosome, the two sexes are not in the same position at all.

A woman has two X chromosomes

So she has two alleles of every X-linked gene, exactly as for any autosomal gene. A recessive allele on one X can be masked by a dominant allele on the other.

A man has one X and one Y

So for most X-linked genes he has only one allele. There is no second copy on the Y to mask it, and whatever that single allele says is what shows.

Why that makes males more often affected

A woman shows a recessive X-linked condition only if she inherits the recessive allele twice — once from each parent. A man shows it if he inherits it once, from his mother. One event is far more likely than two, which is why conditions such as haemophilia and red-green colour blindness are seen much more often in men.

Dominant and recessive still mean the same thing

Nothing about dominance has changed. What has changed is that a male has no second allele for the dominant one to be dominant over. A single recessive allele shows in him not because it has become dominant, but because it is unopposed.

One copy is enough in a male

Genes on the X chromosome are sex-linked. A female has two alleles and can carry a recessive one hidden; a male has only one, so a single recessive allele shows in him.